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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadbox protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liverOur in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studiedgenes in HepG2 cells—a human liver cancer cell line.–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

Keywords： Epigenetics     Hepatocyte nuclear factor 1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkheadbox protein A2 (FOXA2)     N-glycosylation     HepG2 cells    

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The Performances of Aerobic and Anaerobic Phosphorus Uptak e and theCharacters of Microorganism in MB（A2

Wu Jian,Wang Shihe

Strategic Study of CAE 2007, Volume 9, Issue 11,   Pages 191-195

Abstract:

Combining membrane bioreactor and A2/O crafts, MB(A222. 30mgP·gMLSS-1·h-1

Keywords： aerobic phosphorus uptake     denitrifying phosphorus removal     phosphate accumulating organisms(PAOs)     electron acceptor    

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Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells.is suggested to be involved in neurofibrillary tangle (NFT) formation, disturbed amyloid precursor proteinBased on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylationFurther studies are required to disclose the role of PP2A in Alzheimer’s disease.

Keywords： protein phosphatase 2A     Alzheimer’s disease     holoenzyme composition     protein phosphatase 2A inhibitors     Leu309    

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Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 275-279 doi: 10.1007/s11684-012-0216-4

Abstract:

PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses toHowever, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesisThis review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in

Keywords： PTPN11/Shp2     leukemia     hepatocellular carcinoma     mutation    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: We constructed a eukaryotic expression plasmid encoding Epstein-Barr virus latent membrane protein 2(EBV, LMP2) and evaluated its effects on humoral immunity.The serum antibody against LMP2 was detected with enzyme-linked immunosorbent assay (ELISA).The serum titer of IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encodingLMP2 was up to 1∶4000.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which are

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: This study aims to demonstrate that blocking the receptor-interacting protein2 (Rip2) expression canconcentration was assayed with ELISA and high-mobility group box 1 protein (HMGB1) level with semi-quantitativeRip2 siRNA plasmid could block the mRNA and protein expression of Rip2 and promote cell proliferationBlocking Rip2 could attenuate LPS-induced TNF-? and HMGB1 production.The results demonstrate that Rip2 siRNA plasmid can block the expression of Rip2, decrease the production
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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, proteinphosphatase 2A (PP2A) activity, and on tau phosphorylation.of Src protein, and the phosphorylation levels of PP2A Y307 and tau at different sites, as well as PP2ATwelve hours after siRNA transfection, the protein level of Src was dramatically decreased, with decreasedHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediatingRecent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional targetrepressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract: protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism isacid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcriptionZinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higherThus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 101-105 doi: 10.1007/s11684-010-0017-6

Abstract: Phospholipase A2 (PLA2) is a crucial element for normal neuro-physiological function.study aims to investigate the genetic association between the polymorphism of cytosolic phospholipase A2(cPLA2) family genes and schizophrenia among Han Chinese in the northern part of China.The genotypic frequency of cPLA2 gene did not deviate from Hardy-Weinberg equilibrium either in caseOur data suggest that many loci in the cPLA2 family genes may be associated with schizophrenia.

Keywords： schizophrenia     cytosolic phospholipase A2     ligase detection reaction     polymorphism    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate     characteristic     study     plasma     resistance    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: Proteinase-activated receptors (PARs) are a novel subclass of seven transmembrane-spanning, G protein-coupledHowever, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.PAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Effect of inlet box on performance of axial flow fans

LI Jingyin, TIAN Hua, YUAN Xiaofang

Frontiers in Energy 2008, Volume 2, Issue 4,   Pages 390-394 doi: 10.1007/s11708-008-0087-1

Abstract: Numerical investigations on 3D flow fields in an axial flow fan with and without an inlet box have beenfan performance caused by the internal flow fields and the velocity evenness at the exit of the inlet boxIt is interesting to find that although the inlet box is well designed in accordance with basic designThis research shows that the inlet box needs further improvement and such a check on the flow fields

Keywords： box     velocity distribution     accordance     Numerical     variation    

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Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract:

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistanceHowever, none of those concepts or views has led to an effective therapy for type 2 diabetes.The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein

Keywords： type 2 diabetes     energy expenditure     inflammation     lipotoxicity     mitochondria     hyperinsulinemia     adenosinemonophosphate-activated protein kinase (AMPK)    

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Title Author Date Type Operation

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

The Performances of Aerobic and Anaerobic Phosphorus Uptak e and theCharacters of Microorganism in MB（A2

Wu Jian,Wang Shihe

Journal Article

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Journal Article

Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Effect of inlet box on performance of axial flow fans

LI Jingyin, TIAN Hua, YUAN Xiaofang

Journal Article

Mechanisms of insulin resistance in obesity

Jianping Ye

Journal Article